What Are The Side Effects of CBD?

CBD has just a few mild side effects, and does not affect the major functions of the body.

In recent years, cannabidiol (CBD) has become a popular remedy for many conditionsincluding anxiety, epilepsy, pain, and MS.

CBD is a non-psychoactive compound found in marijuana. Unlike THC, CBD does not cause a euphoric high or mind-altering effects.

CBD interacts with the endocannabinoid system, which has far-reaching effects on the whole body. It has antiemetic, anticonvulsant, antipsychotic, and analgesic properties, among many others.

As interest in CBD’s benefits has surged, so has interest in its potential side effects. Overwhelmingly, research suggests that CBD has only a few mild side effects including fatigue, appetite changes, diarrhea, and changes in the metabolism of other drugs.

When compared to other drugs, CBD’s list of side effects is quite short. They are also more common if you’re using a very high dose.

Risks and Side Effects of CBD

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Overall, CBD is considered to be well-tolerated in humans, even at high doses or when taken for long periods of time. Unlike THC, CBD does not have any psychoactive side effects.

Most people do not experience side effects from using CBD. Several animal and human studies have reported no side effects of treatment with CBD. However, other studies have reported a few minor side effects that may affect some people.

The most common side effects of CBD include:

  • Fatigue
  • Appetite changes
  • Diarrhea
  • Changes in the liver’s ability to process drugs

Other possible side effects:

  • Worsening of HIV symptoms
  • Reduction of fertility

CBD can be safely used at high doses without negative effects. Doses of up to 1500mg per day have been reported as safe. For reference, some people benefit from doses as low as 15mg.

Studies show that the lethal dose of CBD is very high. Scientists are not sure of the exact lethal dose of CBD in humans, as there are no known reports of death caused by CBD. A 1981 study found that a dose of 200mg per kg of body weight caused death in rhesus monkeys.

What Do Studies Say?

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2011 review of 132 scientific studies concluded that CBD has very few side effects and does not majorly impact bodily functions.

Essential bodily functions such as heart rate, body temperature, blood pressure, motor functions, psychological function, and gastrointestinal transit were found to be unaffected by CBD.

The major side effects included CBD’s impact on liver metabolism of certain drugs, a possible worsening of HIV symptoms, and a possible impact on fertility.

Another group of researchers reviewed the safety and side effects of CBD in 2017. Many studies on CBD were conducted between 2011 and 2017, so the researchers were able to review an additional 74 articles.

This group of researchers found mild side effects of CBD, including fatigue, diarrhea, and changes in appetite.

Effect on Drug Metabolism

CBD can affect the liver’s ability to process certain drugs and medications.

In a 2011 review, scientists found that CBD was a “potent inhibitor” of liver enzymes involved in drug metabolism.

A class of liver enzymes called cytochrome P450 is involved in metabolizing many drugs. CBD inactivates specific forms of this enzyme, making the liver less effective at processing certain drugs. This is very similar to the way that grapefruits can interact with medications.

This means that if you take any prescription medications, it’s important to talk to your doctor before combining them with CBD.

Fatigue

2014 study of medical marijuana users found that patients treated with high-CBD strains experienced fatigue.

However, the marijuana used in the experiment contained some THC, so it is not clear to what extent the drowsiness can be attributed to CBD. THC is known to induce sleepiness.

2015 study on CBD’s effectiveness for epilepsy found that tiredness was the most commonly reported side effect of the drug.

Diarrhea

Diarrhea was reported as a common side effect of CBD treatment in a 2015 study on CBD for epilepsy.

However, it is not clear whether this side effect is specific to those with epilepsy, as it was found in other studies that CBD does not impact gastrointestinal transit time (which would be shortened in the case of diarrhea).

It’s also important to note that the doses used in the study were extremely high.

Appetite Changes

A few studies have reported changes in appetite resulting from CBD use.

In a Dutch study from 2014, people who used a high-CBD strain of marijuana reported mild changes in their appetite. However, appetite changes were stronger in those who used a high-THC strain.

Since there was still THC in the high-CBD strain, it’s difficult to tell whether the effects are due to CBD.

Effect on HIV Patients

In a 2011 review, researchers concluded that CBD may worsen the disease progression of HIV. They also found results that suggested it could make it easier to become infected with HIV if exposed to the virus.

The researchers note that some studies found a biphasic effect: a beneficial effect at low doses, and a negative effect at high doses.

However, these side effects only impact those who have been exposed to or infected with the HIV virus.

Fertility

1986 study found that male rats who were exposed to CBD produced 20% less sperm than controls. They also produced significantly fewer live offspring.

Even more interestingly, male offspring of female rats exposed to CBD also produced 20% less sperm, even if they were only exposed in the womb.

Other studies have reported that CBD can impact levels of sex hormones such as including progesterone, testosterone, and estradiol.

Overall, it’s a good idea to avoid the use of drugs, including CBD, if you are trying to conceive.

How To Reduce Side Effects

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If you would like to reduce your chances of experiencing side effects from CBD, it’s important to use the correct dose and make sure any medications you are taking do not interact with CBD.

When trying to determine the correct dosage for patients, doctors often use a process called titration. Titration involves slowly increasing the dose until the patient achieves the most relief of symptoms with minimal side effects.

If you are experiencing side effects, you may be using too high of a dose. You can use dose titration to find a dose that works for you, but does not produce side effects.

When it comes to any medication, it’s always better to use the smallest dose that works. Since side effects increase with dosage, a smaller dose means you will have a lower chance of experiencing negative side effects.

It’s also important to talk to your doctor about any drug interactions between CBD and any medications you are currently taking.

Summary

CBD can be helpful for a number of conditions, but it may cause mild side effects in some people. These include fatigue, appetite changes, diarrhea, and changes in the liver enzymes responsible for drug metabolism.

For those who have been exposed to HIV, or who are trying to conceive a child, CBD may have negative side effects. It’s recommended to avoid using CBD if you are in one of these categories.

It’s important to get the dose right to minimize your risk of side effects from CBD. If you always use the smallest dose that gives you relief, you will be less likely to experience side effects.

Because CBD can interfere with the metabolism of some drugs, it’s a good idea to check with your doctor before combining CBD with other medications.

Trending: Cannabis Terpenes in the Kitchen

Terpenes are the oils in various plants, such as basil and lavender, that give them their signature scents and flavors. Cannabis boasts over 100 different terpenes that vary from strain to strain. They differ from THC in that they don’t get you high, but, like CBD, are thought to have a variety of health benefits. For instance, limonene has a pleasant citrus aroma, and may also elevate your mood. Myrcene is an earthier terpene, which is believed to have a calming effect.

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Terpenes derived from other plants—that basil, for instance, or an orange essential oil—have long been one of many items in the chef’s arsenal, and thanks to their natural pungency, terpenes are now popping up more and more often in the culinary scene. Specifically, chefs are discovering cannabis terpenes as useful additives to food, cocktails, beer, and more.

Aaron Ziegler of Bull & Dragon is a Los Angeles-based chef who specializes in private dinners and events, and, on occasion, offers private cannabis-infused meals. He said he experiments with cannabis terpenes in the same way he might incorporate any other herb or plant, noting that chefs are trained to use their nose and tongue as a science lab, quickly sussing out how a particular item might be used. “It’s a lot like discovering any other unique ingredient, like a spice from Malaysia or Peru or something, where you haven’t used that smell or flavor profile before. It’s like, ‘let’s explore this,’ and ‘how many ways can I work this into my food?’” he said.

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Ziegler might use a controlled heat extraction method for a “cooked” quality, or a CO2 extraction, which can work with a clean flower that has been grown with absolutely no sprays or chemicals. Those latter terpenes “have this bright, wonderful flavor,” he said. “Some of them—in particular, some of the indicas I’ve found—can be spicy, [with a] really peppery note to them.”

For instance, he’s found success using the strain Green Crack, which contains the terpene myrcene, when making mozzarella cheese. “I use a CO2 extraction, so it’s the natural oil of the plant,” he said. “I bloomed that in lemon juice, and I used that as my culture to make mozzarella cheese. So now, I have this terpene and sativa-infused cheese that has this herbaceous mozzarella flavor. It’s really floral, and it works just like any other herb-infused cheese.”

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He’s also used the Grape Ape strain, along with lavender, to make an ice cream that he says tastes just like blueberry ice cream, despite the fact that there are no blueberries in it. Ziegler even sees potential in fresh, uncured flowers as a garnish on various dishes. “There’s no transfer of [THC] at that point; the body can’t digest it in that form,” he said. “To use [cannabis] in that sense is really fun, and that’s all about the terpenes.”

At Prank Bar in downtown Los Angeles, owner Dave Whitton first learned about terpenes via his brother-in-law, who opened one of Nevada’s earliest dispensaries. Prank Bar now uses them in cocktails, like the Mon Frere, with gin, orange bitters, and limonene terpenes. They also add them to three different house-made kombuchas, which are available on draft. Though Prank’s offerings contain no THC or CBD at this time, Whitton says his staff enjoys them primarily for the health benefits they seem to produce.

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He also said he’s noticed an elevated mood and increased energy since becoming a daily drinker of terpene kombuchas. Their house kombucha, for one, is made with mango, ginger, peach, and coconut with limonene terpenes added. “There’s a really sharp edge to the ginger without the terpenes, but when you put the terpenes on top, it creates a cover,” Whitton said. “It’s different from bitters. Bitters create a body underneath, but with terpenes, the oils hover on top and add this delicate softener to those edgier ingredients.”

Prank’s “Calm Booch” is a delicious blend of tart cherry, lavender, and myrcene, a terpene also found in mangoes that studies indicate may have a sedative effect; their “Cross Fizz,” a pineapple mint kombucha, incorporates limonene and pinene terpenes. “That pinene terpene is a bronchodilator, along with the anti-inflammatory [properties]. It’s great for breathing which is why we call it Cross Fizz. If you’re going to go work out, you’re going to get that boost,” Whitton said. “Not only are the flavonoids really fun to play with, but the health benefits [of terpenes] are extraordinary.” Whitton said that in the last six months, Prank has sold twice as much kombucha their most popular beer.

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That isn’t to say you can’t pair beer and terpenes. It’s an avenue Prank is looking to explore in the near future, and it’s one that California-based Lagunitas Brewing Co. already has. In August, Lagunitas released SuperCritical, an IPA brewed with terpenes. Lagunitas Director of Communications Karen Hamilton says the beer has “a faint cannabis-ish aroma,” but is a still “smooth, flavorful IPA-style beer” that’s been getting a great response from their customers. The same has been true at a bar called Flore in San Francisco, where CBD beer is on draft, and CBD and terpenes add flavor and wellness benefits to cocktails and mocktails on the 4:20 Happy Hour menu.

“You can consider terpenes like a new spice in your spice rack,” says Hamilton. “It brings an interesting flavor to the beer that we have not used before.”

Cannabis Terpene Cocktails—Healthy and . . . Herbal

At this point, it’s hard to be surprised by any ingredient in a cocktail made by a creative mixologist. Duck fat? It’s been done. Peanut butter? Why not. Charcoal? Absolutely. Every veggie in the garden? Old hat. So it only makes sense that these bartending Picassos have to dig ever deeper to find additives that will not just stand out but add that something extra-special to their Instagram-worthy concoctions.

It’s not shocking that Gracias Madre—the Mexican-themed cousin of L.A.’s cultish plant-based Café Gratitude chain—made digital waves last year when introducing CBD-infused cocktails, which don’t exactly not taste of marijuana. By now, many people are familiar with CBD (also known as cannabidiol), the trendy part of cannabis or hemp that’s being increasingly touted for medical use as an anti-inflammatory, pain-easing mood elevator said to not elicit a true high, since it has lower levels of THC (the psychoactive portion of the plant that largely comes from the flower). The herbal supplement brand Torii Labs has even been mixing its CBD-laced Re-Leaf tonic with Gem & Bolt’s mezcal distilled with damiana (a heart-opening medicinal shrub), lemon, honey, and ginger for the High Frequency, designed to connect the heart and mind and leave the drinker with lingering positive energy.

The bar at Prank

The bar at Prank

Photo: Courtesy of Prank

At this point, CBD is relatively old news, and it’s all about terpenes, a term wellness junkies and the rest of the world may soon begin hearing more of, especially if Los Angeles’s Prank bar has any say in the matter. One thing to note: CBD is generally only allowed where medical or recreational marijuana is legal, while terpenes are legal in the U.S. You can think of terpenes as similar to the flavonoids inside any plant—they are in everything from lavender to basil to cannabis and help give something its flavor, whether it’s in a certain strain of weed or a sprig of rosemary. The reason the rise of these incredibly refined terpenes is so exciting, says Prank co-owner and veteran L.A. barman Dave Whitton, is they have hefty health benefits alongside interesting flavor profiles.

Terpenes from cannabis have some of the strongest anti-inflammatory properties of any plant, according to proponents, and a good number of doctors are now studying their effects and benefits in replacing opioids. “When you toss in CBD, you’re getting the different terpenes but not really distinctive ones,” says Whitton. “Once you dive in and distill it down, you clean out the terpene itself and keep cleaning it and cleaning it using CO2 extraction until you get this very distinct strain line that’s an oil.”

A few of the more than 140 identified thus far include limonene, a pungent citrus-oriented terpene, which, in addition to the mighty anti-inflammatory benefits they are all said to carry, is credited as being stress relieving, mood elevating, relaxing, antibacterial, antifungal, anticarcinogenic, and has been used to treat acid reflux and gallstones. At Prank, which opened earlier this year as L.A’.s first walk-up bar (the airy neighborhood-friendly industrial space features vibrant tile work and a display case of terpene chocolates, kombucha, and CBD lotions, among other related products), it’s the softly acidic note that rounds out the bright and boozy Mon Frére, which combines Plymouth gin with Cocchi Americano and orange bitters. “You’re taking a depressant, alcohol, and putting in a mood lifter,” says Whitton, “so hopefully it evens things out a little bit. That’s why we like using it in cocktails.”

All it takes is a drop or two to have an effect on the person and the flavor. Limonene also features in the instantly addictive Fizziotics House Original Kombucha. It’s fermented into the health beverage in-house, along with flavors of mango, peach, coconut, and ginger. (Another called Crossfizz, with pomegranate and ginger, is new this month.) The piney-tasting pinene terpene—said to be a bronchodilator good for those with asthma that can be used as an expectorant and to increase alertness—also factors into that brew.

Another key terpene for Prank is myrcene, with a distinct clove scent and flavor and a higher viscosity than the others. “It’s more of a sedative effect, a muscle relaxer,” says Whitton, adding it’s also a great sleep aid. In the Blue Hilaria, with root honey, citrus, Johnnie Walker Black Label, and a floater of Johnnie Walker Blue Label, it’s evident from the first sip—no straw comes in the glass, so the drinker tastes the myrcene and top-shelf booze lingering on the surface. A new kombucha with this terpene is in the works, too: “Ten minutes into drinking a Calmbucha, if you’re cognizant, you’ll start to notice you’re a little more relaxed. Your shoulders will move down, you’ll feel a little bit better,” says Whitton.

While it’s by no means advised to drink terpene cocktails on the daily, Whitton says the potent wonder ingredient is something that should be taken regularly for optimal results: “If you do, the less inflammation you’ll have and the better you’re going to feel, especially the seventh day compared to the first.” But come fall, drinkers at Prank will be privy to even more of these finely crafted cocktails, especially with the seasonally appropriate pinene and myrcene, which Whitton is excited to pair with pumpkin and ginger. And next year, some of the organic and healthy yet totally delicious dishes may be served with dressings or sauces infused with the oils, too. “We have about 15 more terpenes we’re playing with,” Whitton says, “but we want to be able to talk about them intelligently, so people understand the benefits to the body.”

The Genes of Terpenes: Scientists Discover Pot’s Smell Predictor

By now, most even casual consumers of marijuana are familiar with “terpenes,” the compounds found in the essential oils of plants, responsible for a plant’s distinctive taste and aroma—and, with cannabis, which also play a role in how the plant affects the mind and body.

But according to a pair of scientists from the University of British Columbia, to find which terpenes a plant will produce, to determine if a cannabis plant will smell like skunk, funk or sweet apple pie, you can look at the plant’s genes.

Let us attempt to explain.

Terpenes are prized not only because they have profound impact on the humans who consume them, but because they’re not predictable. Similar or identical strains of cannabis will produce different levels of terpenes. (And as anyone who’s waded into cannabis genetics can tell you, “identical” strains, i.e. two varieties of Blue Dream, will have very different genetic makeups.) We have a fine idea of what terpenes are and what they do, but less of a handle on how to predict with precision what terpenes a finished product will have, and why.

“Concentrations and ratios of cannabinoids are relatively predictable for different strains,” the researchers wrote, “but terpene profiles are often unknown or unpredictable.”

We have a better idea now.

As reported in an article published in the journal Plos One on Wednesday, after studying both the genetic makeup and the terpene count of a variety of hemp called “Finola” and in a cut of Purple Kush, researchers Judith K. Booth, Jonathan E. Page and Jörg Bohlmann believe they’ve identified as many as 30 genes that may predict how a plant produces and synthesizes terpenes.

Check out www.mrterps.com for many award winning terpenes.

As the Vancouver Sun reported, the scientists looked at the genomes of cannabis plants to identify genes associated with resulting terpenes, or which genes lead to “terpene biosynthesis,” as they wrote. They believe they’ve found a “cannabis terpene synthases gene family”—that is, a set of genetic markers that determine how a plant produces terpenes—associated with terpenes including mycrene and limoene, the “fruity” and “piny” flavors found in many strains of popular cannabis, including Cookies, GG#4 and O.G. Kush.

What to do with this information, and why should you care?

Consumers can look forward to more and better terpy products, for one. Armed with this information, plant scientists can breed a plant to produce terpenes, or at least know what starting-off seed material will produce an aromatic product.

This is also a major step forward in cannabis genetics.

For a long time, plant breeding was focused on traits that would predict levels of THC and CBD. Now, we know terpenes play a role, along with cannabinoids, in determining a plant’s effect.

After this first step towards predicting a plant’s terpene count, someday, we may be able to expect marijuana producers to make available finely-tuned cannabis, for precisely the effect we’re seeking.

Thanks, science.

eSense-Lab clinches terpene distribution agreement for lucrative UAE market

eSense-Lab (ASX: ESE) has clinched a A$1.1 million distribution agreement to take its plant-based terpene strains to the United Arab Emirates market.

The company secured the three-year binding sales and distribution contract with IC ACCESS, which has a minimal annual commitment of A$366,000.

As part of the agreement eSense-Lab will modify its terpene product line to suit the United Arab Emirates market and IC will have an exclusive right to market, sell and distribute the products in the region.

“United Arab Emirates is an extremely attractive market, with many applications for our products,” eSense-Lab chief executive officer Haim Cohen said.

“The United Arab Emirates has unique needs and new applications for our terpenes strains may arise from this market,” he said, adding IC had the means and connections to ensure implementation of the terpene products in the United Arab Emirates market.

This latest distribution deal follows a memorandum of understanding in mid-December with Australian brewer Young Henry’s Brewing Company to develop a line of terpene infused beer products.

Meanwhile, in November last year, eSense-Lab finalised its beta cannabis terpene infused chocolate with Healthy Chocolate Florida in an attempt to get a foothold in the United States’ US$4.5 billion retail cannabis market.

According to eSense-Lab, the companies are working on the product’s consumer requirements and are targeting finalising the product by mid-year.

eSense-Lab created the world’s first natural reformulated cannabis terpene profiles. The company has 10 formulations available and is developing a further 20.

The company claims its terpenes provide health and medical benefits including its cannabis-based formulations.

Medicinal cannabis market

eSense-Lab joins the ranks of numerous ASX-listed medicinal cannabis stockstaking advantage of easing restrictions across the world to develop cannabis-based products for a myriad of purposes.

US cannabis retail sales are anticipated to have grown 30% during 2017 on 2016 levels, with the global market forecast to be valued at $500 billion by 2029.

Shares in e-Sense-Lab were at A$0.29 in mid-morning trade up 1.75%.